I created a tiny CLI (command line interface), launch-epub that wraps Readium's Cloud Reader in a Node application. Once installed, simply run launch-epub from within the EPUB project directory or followed by a path to the EPUB file or project directory as the first argument. The program will mount an EPUB in a specially configured instance of live-server and launch the reader (with the EPUB sideloaded) in the browser for development needs.

Using Zeit's Pkg, I packaged it as a self-contained executable for sharing with frontend team members who are not as famililar with the command line or Node.

Link to repo: https://github.com/thephilgray/launch-epub